Epilepsy is one of the most common disorder of man and one of very difficult disorders to manage in medical practice. Although estabilished drugs have been used, they have also proved a lack of efficacy for several types of seizure. A large
number
of
candidate drug used antiepileptive drugs are undergoing preclinical and clinical evaluation throughout the world. Now, felbamate, gabapentin, lamotrigine, zonisamide, vigabatrin, clobazam are promising of new generation of drugs in epilepsy
management.
Our purpose in this review is to consider the basic mechanism about currently used new antiepileptic drugs and newly develped drugs. Also, through the history of discovery of new antiepileptic drugs, we are going to approach to the next
generation
of
epilepsy in pathophysiology, pharmacology, and medical practice.
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